反应详情

温度

110 °C

A solution of N-tert-butyl-4-methyl-3-nitrobenzenesulfonamide (5.89 g, 21.6 mmol) in N,N-dimethylformamide dimethyl acetal (10 ml) was stirred with heating at 110° C. for 10 hr. The reaction solvent was evaporated under reduced pressure and diethyl ether was added. The precipitated solid was collected by filtration, washed with diethyl ether and dried in vacuo to give N-tert-butyl-4-((E)-2-dimethylaminovinyl)-3-nitrobenzenesulfonamide (5.41 g, yield 76.6%).

1. customThe reaction solvent was evaporated under reduced pressure and diethyl ether
2. additionwas added
3. filtrationThe precipitated solid was collected by filtration
4. washwashed with diethyl ether
5. customdried in vacuo