反应详情

14.5 g of the 4-[(4-dipropylaminobutyl)methylamino]methylbenzylamine hydrochloride (13a) obtained was dissolved in 73 ml of water. After the addition of 146 ml of a 1N sodium hydroxide aqueous solution, the product was extracted with 200 ml of hexane, followed by 100 ml of hexane. The organic layer was washed with 100 ml of water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure, thereby obtaining 10.1 g of 4-[(4-dipropylaminobutyl)methylamino]methylbenzylamine (13) as a colorless oily substance (yield: 95%, GC: 99.7%).

1. extractionthe product was extracted with 200 ml of hexane
2. washThe organic layer was washed with 100 ml of water
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationconcentrated under reduced pressure