Sodium Hydroxide → HCID 59850551, compound

Participants

Reaction Steps

14.5 g of the 4-[(4-dipropylaminobutyl)methylamino]methylbenzylamine hydrochloride (13a) obtained was dissolved in 73 ml of water. After the addition of 146 ml of a 1N sodium hydroxide aqueous solution, the product was extracted with 200 ml of hexane, followed by 100 ml of hexane. The organic layer was washed with 100 ml of water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure, thereby obtaining 10.1 g of 4-[(4-dipropylaminobutyl)methylamino]methylbenzylamine (13) as a colorless oily substance (yield: 95%, GC: 99.7%).

Provenance & Evidence