Sodium borohydride → HCID 67315794, compound

HRID 1012589Notes

Reaction equation

HRID 1012589 reaction equation
[CH2:1]([N:4]([CH2:26][CH2:27][CH3:28])[CH2:5][CH2:6][CH2:7][CH2:8][CH:9]([NH2:25])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([CH2:17][N:18]=[CH:19][C:20]2[NH:21][CH:22]=[CH:23][N:24]=2)=[CH:13][CH:12]=1)[CH2:2][CH3:3].[BH4-].[Na+]>CO>[CH2:26]([N:4]([CH2:1][CH2:2][CH3:3])[CH2:5][CH2:6][CH2:7][CH2:8][CH:9]([NH2:25])[CH2:10][C:11]1[CH:12]=[CH:13][C:14]([CH2:17][NH:18][CH2:19][C:20]2[NH:21][CH:22]=[CH:23][N:24]=2)=[CH:15][CH:16]=1)[CH2:27][CH3:28]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 136343960HCID 136343960, compound

Product 1

HCID 67315794HCID 67315794, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

560 mg (1.46 mmol, 1.0 equivalent) of {(4-dipropylaminobutyl)-[4-(1H-imidazol-2-ylmethylidene)aminomethylbenzyl]methyl}amine (43) and 12 ml of methanol were charged in a 50 ml recovery flask under a nitrogen stream. The mixture was then stirred. 113 mg (2.92 mol, 2.0 equivalents) of sodium borohydride was added to the mixture at 0° C. The mixture was then stirred at 0° C. for one hour and at 20° C. for one hour.

Workup

  1. stirringThe mixture was then stirred at 0° C. for one hour and at 20° C. for one hour

Sources & evidence

ORD record
ord-c2fc03eab0b64b5fa2eaffe9aff03c5c
Source dataset
uspto-grants-2011_07
Patent number
US07977512B2

Reaction notes

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