O-((2-methylthiazol-4-yl)methyl)hydroxylamine → 3-[2-Chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-N-(2-methyl-thiazol-4-ylmethoxy)-benzamide
반응식
[Cl:1][C:2]1[CH:19]=[C:18]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=2[F:28])[CH:17]=[CH:16][C:3]=1[C:4]([C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:9](O)=[O:10])=[O:5].[CH3:29][C:30]1[S:31][CH:32]=[C:33]([CH2:35][O:36][NH2:37])[N:34]=1>>[Cl:1][C:2]1[CH:19]=[C:18]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=2[F:28])[CH:17]=[CH:16][C:3]=1[C:4]([C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:9]([NH:37][O:36][CH2:35][C:33]1[N:34]=[C:30]([CH3:29])[S:31][CH:32]=1)=[O:10])=[O:5]참가 물질
3
실험 절차
Compound 424 (50 mg, 0.12 mmol) and O-(2-Methyl-thiazol-4-ylmethyl)-hydroxylamine (36 mg, 0.25 mmol) were treated as described for compound 337. Flash chromatography (ethyl acetate/petroleum ether: graduated from 67/33 to 100/0) provided the title compound. 1H NMR (CDCl3) δ 10.0-9.0 (bs, 1H), 7.76 (dd, 1H), 7.67 (d, 1H), 7.42-7.30 (m, 3H), 7.15 (s, 1H), 7.00-6.84 (m, 3H), 6.75 (dd, 1H), 5.98 (bs, 1H), 5.04 (s, 2H), 2.64 (s, 3H), 2.45 (s, 3H)
출처 및 근거
- ORD 기록
- ord-fcd0a38861454805b85a9b91e420a008
- 출처 데이터셋
- uspto-grants-2011_07
- 특허 번호
- US07977387B2
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