O-((2-methylthiazol-4-yl)methyl)hydroxylamine → 3-[2-Chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-N-(2-methyl-thiazol-4-ylmethoxy)-benzamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	O-((2-methylthiazol-4-yl)methyl)hydroxylamine	HCID 425143	—
Edukt	3-[2-Chloro-4-(2,4-difluorophenylamino)benzoyl]-4-methylbenzoic acid	HCID 58677602	—
Produkt	3-[2-Chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-N-(2-methyl-thiazol-4-ylmethoxy)-benzamide	HCID 11261047	—

Reaktionsschritte

Compound 424 (50 mg, 0.12 mmol) and O-(2-Methyl-thiazol-4-ylmethyl)-hydroxylamine (36 mg, 0.25 mmol) were treated as described for compound 337. Flash chromatography (ethyl acetate/petroleum ether: graduated from 67/33 to 100/0) provided the title compound. 1H NMR (CDCl3) δ 10.0-9.0 (bs, 1H), 7.76 (dd, 1H), 7.67 (d, 1H), 7.42-7.30 (m, 3H), 7.15 (s, 1H), 7.00-6.84 (m, 3H), 6.75 (dd, 1H), 5.98 (bs, 1H), 5.04 (s, 2H), 2.64 (s, 3H), 2.45 (s, 3H)

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07977387B2
Quelldatensatz	uspto-grants-2011_07
ORD ID	ord-fcd0a38861454805b85a9b91e420a008
Quellennotiz	uspto-grants-2011_07