HRID1012669

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID120426

Hydroxylamine, O-(p-methoxybenzyl)-

C8H11NO2

结构：Cc1ccc(C(=O)O)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1Cl

HCID58677602

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CONC(=O)c2ccc(C)c(C(=O)c3ccc(Nc4ccc(F)cc4F)cc3Cl)c2)cc1

HCID58677577

未命名化合物

PROCEDURE

实验过程

Compound 424 (100 mg, 0.25 mmol) and O-(4-methoxy-benzyl)-hydroxylamine (65 mg, 0.34 mmol) were treated as described for compound 337. Flash chromatography (ethyl acetate/petroleum ether: graduated from 80/20 to 60/40) provided the title compound. 13C NMR (CDCl3) δ 195.3, 165.6, 160.1, 159.3 (dd), 155.7 (dd), 148.2, 142.1, 139.7, 135.3, 133.8, 131.7, 131.1, 129.4, 129.1, 128.6, 127.8, 127.2, 124.6 (dd), 124.2 (dd), 116.2, 114.1, 112.8, 111.6 (dd), 105.0 (dd), 78.0, 55.3, 20.4