O-((4-Methoxyphenyl)methyl)hydroxylamine → HCID 58677577, compound

Participants

Role	Name	HCID	Charge
Reactant	O-((4-Methoxyphenyl)methyl)hydroxylamine	HCID 120426	—
Reactant	3-[2-Chloro-4-(2,4-difluorophenylamino)benzoyl]-4-methylbenzoic acid	HCID 58677602	—
Product	HCID 58677577	HCID 58677577	—

Reaction Steps

Compound 424 (100 mg, 0.25 mmol) and O-(4-methoxy-benzyl)-hydroxylamine (65 mg, 0.34 mmol) were treated as described for compound 337. Flash chromatography (ethyl acetate/petroleum ether: graduated from 80/20 to 60/40) provided the title compound. 13C NMR (CDCl3) δ 195.3, 165.6, 160.1, 159.3 (dd), 155.7 (dd), 148.2, 142.1, 139.7, 135.3, 133.8, 131.7, 131.1, 129.4, 129.1, 128.6, 127.8, 127.2, 124.6 (dd), 124.2 (dd), 116.2, 114.1, 112.8, 111.6 (dd), 105.0 (dd), 78.0, 55.3, 20.4

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07977387B2
Source dataset	uspto-grants-2011_07
ORD ID	ord-9d1e77b71cd94ab7a0ce6ae74f8781a9
Source note	uspto-grants-2011_07