4-Morpholinamine, hydrochloride (1:1) → 3-[2-Chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-N-morpholin-4-yl-benzamide

HRID 1012671Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1012671
[Cl:1][C:2]1[CH:19]=[C:18]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=2[F:28])[CH:17]=[CH:16][C:3]=1[C:4]([C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:9](O)=[O:10])=[O:5].Cl.[NH2:30][N:31]1[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1>>[Cl:1][C:2]1[CH:19]=[C:18]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=2[F:28])[CH:17]=[CH:16][C:3]=1[C:4]([C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:9]([NH:30][N:31]1[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1)=[O:10])=[O:5]

Komponenten

3

Edukt 2

HCID 122606304-Morpholinamine, hydrochloride (1:1)HCID 586776023-[2-Chloro-4-(2,4-difluorophenylamino)benzoyl]-4-methylbenzoic acid

Produkt 1

HCID 114658833-[2-Chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-N-morpholin-4-yl-benzamide

Versuchsvorschrift

Compound 424 (50 mg, 0.12 mmol) and N-amino-morpholine hydrochloride (35 mg, 0.25 mmol) were treated as described for compound 337. Flash chromatography (ethyl acetate/petroleum ether: graduated from 67/33 to 100/0) provided the title compound. 13C NMR (DMSO-d6) δ 194.5, 168.2, 158.9 (dd), 155.8 (dd), 149.5, 139.1, 138.2, 133.7, 133.7, 132.9, 131.3, 129.3, 127.5, 126.5 (dd), 126.5, 124.3 (dd), 114.8, 112.0 (dd), 111.9, 105.1 (dd), 66.0, 19.7

Quellen und Nachweise

ORD-Eintrag
ord-87f77409c85740ebad38a50c72341ee8
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07977387B2

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