4-Morpholinamine, hydrochloride (1:1) → 3-[2-Chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-N-morpholin-4-yl-benzamide

참여 물질

역할	이름	HCID	투입량
반응물	4-Morpholinamine, hydrochloride (1:1)	HCID 12260630	—
반응물	3-[2-Chloro-4-(2,4-difluorophenylamino)benzoyl]-4-methylbenzoic acid	HCID 58677602	—
생성물	3-[2-Chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-N-morpholin-4-yl-benzamide	HCID 11465883	—

반응 단계

Compound 424 (50 mg, 0.12 mmol) and N-amino-morpholine hydrochloride (35 mg, 0.25 mmol) were treated as described for compound 337. Flash chromatography (ethyl acetate/petroleum ether: graduated from 67/33 to 100/0) provided the title compound. 13C NMR (DMSO-d6) δ 194.5, 168.2, 158.9 (dd), 155.8 (dd), 149.5, 139.1, 138.2, 133.7, 133.7, 132.9, 131.3, 129.3, 127.5, 126.5 (dd), 126.5, 124.3 (dd), 114.8, 112.0 (dd), 111.9, 105.1 (dd), 66.0, 19.7

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07977387B2
출처 데이터셋	uspto-grants-2011_07
ORD ID	ord-87f77409c85740ebad38a50c72341ee8
출처 메모	uspto-grants-2011_07