2,4-Difluoroaniline → HCID 67314224, compound

HRID 1012673Notes

Reaction equation

HRID 1012673 reaction equation
[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:19])[C:11]2[CH:16]=[CH:15][C:14](Br)=[CH:13][C:12]=2[Cl:18])=[C:6]([CH3:20])[CH:5]=1.[F:22][C:23]1[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:24]=1[NH2:25]>>[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:19])[C:11]2[CH:16]=[CH:15][C:14]([NH:25][C:24]3[CH:26]=[CH:27][C:28]([F:30])=[CH:29][C:23]=3[F:22])=[CH:13][C:12]=2[Cl:18])=[C:6]([CH3:20])[CH:5]=1

Participants

3

Reactant 2

HCID 97092,4-DifluoroanilineHCID 67314846HCID 67314846, compound

Product 1

HCID 67314224HCID 67314224, compound

Procedure

Compound 534 (184 mg, 0.50 mmol) and 2,4-difluoroaniline (0.066 mL, 0.65 mmol) were treated as described for compound 529. Flash chromatography (ethyl acetate/petroleum ether: graduated from 0/100 to 20/80) gave the title compound.

Sources & evidence

ORD record
ord-8fbc12630bf5458da9579e69e60a5995
Source dataset
uspto-grants-2011_07
Patent number
US07977387B2

Reaction notes

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