反应详情

温度

80 °C

3.42 ml of 2 M sodium carbonate solution and 83.5 mg (0.11 mmol) of PdCl2(dppf) are added to a solution of 619.1 mg (2.28 mmol) of methyl 7-bromo-1-benzothiophene-2-carboxylate (Example 6A) and 520 mg (2.51 mmol) of 4-(4-morpholinyl)phenylboronic acid in 10 ml DMF. The mixture is heated at 80° C. for 16 h. Cooling is followed by filtration through kieselguhr and purification by preparative HPLC. The concentrated product is dried under high vacuum. 146.7 mg (16.4% of theory) of the title compound are obtained.

1. temperatureCooling
2. filtrationis followed by filtration through kieselguhr and purification by preparative HPLC
3. customThe concentrated product is dried under high vacuum