反应详情

温度

70 °C

0.67 ml of 2 M sodium carbonate solution and 18.3 mg (0.02 mmol) of PdCl2(dppf) are added to a mixture of 200 mg (0.45 mmol) of N-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-7-bromo-1-benzothiophene-2-carboxamide hydrochloride (Example 22A) and 68.1 mg (0.45 mmol) of 2-methoxyphenylboronic acid in 2 ml of DMF. The reaction mixture is heated at 70° C. for 17 h and, after cooling, filtered through kieselguhr and purified by preparative HPLC. The product fractions are concentrated, taken up in a 5:1 mixture of methanol and 1N hydrochloric acid and again concentrated. Drying under high vacuum results in 112 mg (588% of theory) of the title compound.

1. temperatureafter cooling
2. filtrationfiltered through kieselguhr
3. custompurified by preparative HPLC
4. concentrationThe product fractions are concentrated
5. additiontaken up in a 5:1 mixture of methanol and 1N hydrochloric acid
6. concentrationagain concentrated
7. customDrying under high vacuum