4-Methylbenzothiazole → HCID 178424116, compound

HRID 1012915Notes

Reaction equation

HRID 1012915 reaction equation
[CH3:1][C:2]1[C:7]2[N:8]=[CH:9][S:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.C(O[C:16](=O)[NH:17][C@H:18]1[CH2:23][CH2:22][C@H:21]([C:24](=[O:29])N(OC)C)[CH2:20][CH2:19]1)(C)(C)C.[O:31]=[C:32]1[NH:37][C:36]2[CH:38]=[C:39](C=O)[CH:40]=[CH:41][C:35]=2[S:34][CH2:33]1>>[CH3:1][C:2]1[C:7]2[N:8]=[C:9]([C:24]([C@H:21]3[CH2:20][CH2:19][C@H:18]([NH:17][CH2:16][C:39]4[CH:40]=[CH:41][C:35]5[S:34][CH2:33][C:32](=[O:31])[NH:37][C:36]=5[CH:38]=4)[CH2:23][CH2:22]3)=[O:29])[S:10][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 182724-MethylbenzothiazoleHCID 109433483-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carbaldehydeHCID 178502731HCID 178502731, compound

Product 1

HCID 178424116HCID 178424116, compound

Procedure

Using 4-methyl-benzothiazole (5 mmol, obtained by reductive deamination of 2-amino-4-methylbenzothiazole), [trans-4-(methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester (2.5 mmol) and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carbaldehyde (0.3 mmol) in according to the same protocol as that described for example 1, steps 1.a to 1.c, the title compound was obtained as a yellowish solid (55 mg).

Sources & evidence

ORD record
ord-8aa29d126a014d658f2c4e421899a594
Source dataset
uspto-grants-2011_07
Patent number
US07981886B2

Reaction notes

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