Benzo(B)Thiophene → HCID 178519276, compound

HRID 1012931Notes

Reaction equation

HRID 1012931 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]2[S:9][CH:8]=[CH:7][C:5]=2[CH:6]=1.C(O[C:15](=O)[NH:16][C@H:17]1[CH2:22][CH2:21][C@H:20]([C:23](=[O:28])N(OC)C)[CH2:19][CH2:18]1)(C)(C)C.[O:30]1[C:35]2[CH:36]=[CH:37][C:38](C=O)=[CH:39][C:34]=2[O:33][CH2:32][CH2:31]1>>[S:9]1[C:8]([C:23]([C@H:20]2[CH2:19][CH2:18][C@H:17]([NH:16][CH2:15][C:38]3[CH:37]=[CH:36][C:35]4[O:30][CH2:31][CH2:32][O:33][C:34]=4[CH:39]=3)[CH2:22][CH2:21]2)=[O:28])=[CH:7][C:5]2[CH:6]=[CH:1][CH:2]=[CH:3][C:4]1=2

Participants

4

Reactant 3

HCID 7221Benzo(B)ThiopheneHCID 2481272,3-Dihydro-1,4-benzodioxin-6-carbaldehydeHCID 178502731HCID 178502731, compound

Product 1

HCID 178519276HCID 178519276, compound

Procedure

Using thianaphthene (5 mmol), [trans-4-(methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester (2.5 mmol) and 2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde (0.4 mmol) according to the same protocol as that described for example 1, steps 1.a to 1.c, the title compound was obtained as a colourless oil which solidified on standing (50 mg).

Sources & evidence

ORD record
ord-dd7ee9b612184208bff09b3f7f6ea380
Source dataset
uspto-grants-2011_07
Patent number
US07981886B2

Reaction notes

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