反应详情

1-(Phenyltlhio)pentane-2,4-dione Stir 1,1-dimethylethyl 2-acetyl-3-oxo-4-(phenylthio)butanoate (1.11 g, 3.60 mmol) in TFA (3 mL) for 20 h at RT. Quench with water (10 mL), and extract using diethyl ether (10 mL). Wash organic layer with water (3×10 mL), dry (MgSO4), concentrate and purify (silica gel chromatography, eluting with 100:0 to 80:20 2-methylpentane:EtOAc) to give the title compound as an orange oil (513 mg, 69%).

1. customQuench with water (10 mL)
2. extractionextract
3. dry with materialWash organic layer with water (3×10 mL), dry (MgSO4)
4. concentrationconcentrate
5. custompurify
6. wash(silica gel chromatography, eluting with 100:0 to 80:20 2-methylpentane:EtOAc)