反应详情

Add 4-chloro-1-thiophen-2-yl-butan-1-one (10 g, 53 mmol), ethylene glycol (8.14 g, 131.2 mmol) and p-toluene sulfonic acid (362 mg, 1.6 mmol) to benzene (150 mL) and heat at reflux for 16 h under a water trap. Cool the reaction to RT and wash with 1 N NaOH solution (100 mL) and brine (150 mL). Dry (sodium sulfate) and concentrate to give the title product as a dark oil (12 g, 97%).

1. temperatureheat
2. temperatureat reflux for 16 h under a water trap
3. temperatureCool
4. customthe reaction to RT
5. washwash with 1 N NaOH solution (100 mL) and brine (150 mL)
6. dry with materialDry (sodium sulfate)
7. concentrationconcentrate