2-(3-(2-Phenyl-1,3-dioxolan-2-yl)propyl)isoindoline-1,3-dione → HCID 23123945, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve 2-[3-(2-phenyl-[1,3]dioxolan-2-yl)-propyl]-isoindole-1,3-dione (38 g, 112.91 mmol) in 2 M methylamine solution in methanol (300 mL) and heat in a sealed tube for 3 h at 50° C. Cool the solution to RT, concentrate and purify (silica gel chromatography, eluting with 25:75 DCM:2 M ammonia in methanol) to give the title compound as an oil (11 g, 47%).

Provenance & Evidence