反应详情

温度

50 °C

Dissolve 2-[3-(2-phenyl-[1,3]dioxolan-2-yl)-propyl]-isoindole-1,3-dione (38 g, 112.91 mmol) in 2 M methylamine solution in methanol (300 mL) and heat in a sealed tube for 3 h at 50° C. Cool the solution to RT, concentrate and purify (silica gel chromatography, eluting with 25:75 DCM:2 M ammonia in methanol) to give the title compound as an oil (11 g, 47%).

1. temperatureCool the solution to RT
2. concentrationconcentrate
3. custompurify
4. wash(silica gel chromatography, eluting with 25:75 DCM:2 M ammonia in methanol)