Succinic Acid → HCID 16004699, compound

HRID 1013125Notes

Reaction equation

HRID 1013125 reaction equation
[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[Cl:9][C:10]1[CH:20]=[CH:19][C:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18][C:12]=2[C:11]=1[N:21]1[C:25]([CH3:26])=[CH:24][C:23]([CH3:27])=[N:22]1>CO>[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[Cl:9][C:10]1[CH:20]=[CH:19][C:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18][C:12]=2[C:11]=1[N:21]1[C:25]([CH3:26])=[CH:24][C:23]([CH3:27])=[N:22]1

Participants

4

Reactant 2

HCID 1110Succinic AcidHCID 16004700HCID 16004700, compound

Product 1

HCID 16004699HCID 16004699, compoundYield 78.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Add succinic acid (55.9 mg, 0.47 mmol) to a solution of 7-chloro-6-(3,5-dimethylpyrazol-1-yl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine (130.5 mg, 0.47 mmol) in methanol (3 mL). Stir the reaction at RT for 15 min, and concentrate to give the title compound (145.19 mg, 78%).

Workup

  1. customthe reaction at RT for 15 min
  2. concentrationconcentrate

Sources & evidence

ORD record
ord-abf78bd9315844cba8252b20c8c730bb
Source dataset
uspto-grants-2011_07
Patent number
US07981882B2

Reaction notes

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