Succinic Acid → HCID 67318095, compound

HRID 1013126Notes

Reaction equation

HRID 1013126 reaction equation
[N:1]1([C:5]2[C:15]3[CH2:14][CH2:13][NH:12][CH2:11][CH2:10][C:9]=3[CH:8]=[CH:7][C:6]=2[Cl:16])[CH2:4][CH2:3][CH2:2]1.[C:17]([OH:24])(=[O:23])[CH2:18][CH2:19][C:20]([OH:22])=[O:21]>CO>[C:17]([OH:24])(=[O:23])[CH2:18][CH2:19][C:20]([OH:22])=[O:21].[N:1]1([C:5]2[C:15]3[CH2:14][CH2:13][NH:12][CH2:11][CH2:10][C:9]=3[CH:8]=[CH:7][C:6]=2[Cl:16])[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 1110Succinic AcidHCID 59799036HCID 59799036, compound

Product 1

HCID 67318095HCID 67318095, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Dissolve 6-(azetidin-1-yl)-7-chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine (63 mg, 0.27 mmol) in methanol (1 mL). Add one equivalent of succinic acid (31 mg, 0.27 mmol) in methanol (1 mL) stir, concentrate to an oil, add anhydrous diethyl ether to precipitate out the solid. Decant the solvent and dry the solid under a stream of nitrogen to give the title compound as a solid.

Workup

  1. concentrationconcentrate to an oil
  2. additionadd anhydrous diethyl ether
  3. customto precipitate out the solid
  4. customDecant the solvent
  5. customdry the solid under a stream of nitrogen

Sources & evidence

ORD record
ord-778113f667554f038fe26a0b6316a6c5
Source dataset
uspto-grants-2011_07
Patent number
US07981882B2

Reaction notes

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