反应详情

To a suspension of 2-Benzo[b]thiophene-5-yl-benzaldehyde (compound PRE14) (3.31 g, 13.9 mmole) in methanol (30 mL) was added at 0-5° C. portionwise NaBH4 (0.528 g, 13.9 mmole). At the end of the addition, the cooling bath was removed and the reaction mixture was stirred at room temperature for 2 h. After concentration, the residue was diluted with water and diethyl ether, the organic layer dried over Na2SO4 and concentrated to give 3.13 g of compound O7 as an orange brown oil (Yield=94%).

1. additionAt the end of the addition
2. customthe cooling bath was removed
3. concentrationAfter concentration
4. additionthe residue was diluted with water and diethyl ether
5. dry with materialthe organic layer dried over Na2SO4
6. concentrationconcentrated