2-Methylindole → HCID 67316116, compound

HRID 1013168Notes

Reaction equation

HRID 1013168 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2.Cl[C:12]1[C:16]2[CH:17]=[CH:18][C:19]([F:21])=[CH:20][C:15]=2[S:14](=[O:23])(=[O:22])[N:13]=1>>[F:21][C:19]1[CH:18]=[CH:17][C:16]2[C:12]([C:10]3[C:9]4[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=4)[NH:3][C:2]=3[CH3:1])=[N:13][S:14](=[O:23])(=[O:22])[C:15]=2[CH:20]=1

Participants

3

Reactant 2

HCID 72242-MethylindoleHCID 20434230HCID 20434230, compound

Product 1

HCID 67316116HCID 67316116, compound

Procedure

The sub-title compound was prepared as described for example 1, step b) using 2-methyl indole and the product from step b). The product did not crystallize upon quenching, and was instead purified by partitioning between DCM and water.

Workup

  1. customThe product did not crystallize
  2. customupon quenching
  3. customwas instead purified
  4. customby partitioning between DCM and water

Sources & evidence

ORD record
ord-6576ea05e1f647c581cd98aff360df3a
Source dataset
uspto-grants-2011_07
Patent number
US07981912B2

Reaction notes

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