2-Methylindole → HCID 67315836, compound

HRID 1013217Notes

Reaction equation

HRID 1013217 reaction equation
[CH3:1][C:2]1[C:6]([CH2:7][N:8]2[CH:16]([OH:17])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]2=O)=[C:5]([CH3:19])[O:4][N:3]=1.[CH3:20][C:21]1[NH:22][C:23]2[C:28]([CH:29]=1)=[CH:27][CH:26]=[CH:25][CH:24]=2>>[CH3:1][C:2]1[C:6]([CH2:7][N:8]2[CH:9]([C:29]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[NH:22][C:21]=3[CH3:20])[C:10]3[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=3)[C:16]2=[O:17])=[C:5]([CH3:19])[O:4][N:3]=1

Participants

3

Reactant 2

HCID 72242-MethylindoleHCID 67316943HCID 67316943, compound

Product 1

HCID 67315836HCID 67315836, compound

Conditions

Temperature
180 °C

Procedure

The product of example 22, step b) (230 mg, 0.89 mmol) was treated with 2-methyl indole (196 mg, 1.5 mmol) and heated (neat) to 180° C. for 1 h. The reaction was cooled and the sub-title product was purified by silica chromatography (EtOAc/Hex).

Workup

  1. temperatureThe reaction was cooled
  2. customthe sub-title product was purified by silica chromatography (EtOAc/Hex)

Sources & evidence

ORD record
ord-07b981124c7b44fb9f3e9a3a4f01b92c
Source dataset
uspto-grants-2011_07
Patent number
US07981912B2

Reaction notes

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