Hydrochloric Acid → HCID 57652728, compound

HRID 1013264Notes

Reaction equation

HRID 1013264 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[CH:12]=[C:11]([C:18]([OH:20])=[O:19])[CH:10]=1.Cl.[CH3:22]O>>[CH3:22][O:19][C:18]([C:11]1[CH:10]=[C:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[O:2][CH3:1])[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[CH:12]=1)=[O:20]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 532254102'-Methoxy-5-nitro[1,1'-biphenyl]-3-carboxylic acid

Product 1

HCID 57652728HCID 57652728, compound

Conditions

Temperature
80 °C

Procedure

2′-Methoxy-5-nitro-biphenyl-3-carboxylic acid (8.62 g, 31.5 mmol) was added to a mixture of MeOH (89 mL) and conc. aqueous HCl (4.9 mL). The reaction mixture was stirred at 80° C. for 24 hours, and then stirred for 18 hours at room temperature. The reaction mixture was filtered, and the resulting solid was washed with MeOH and dried to give 8.2 g of 2′-methoxy-5-nitro-biphenyl-3-carboxylic acid methyl ester, MS (M+H)=288.

Workup

  1. stirringstirred for 18 hours at room temperature
  2. filtrationThe reaction mixture was filtered
  3. washthe resulting solid was washed with MeOH
  4. customdried

Sources & evidence

ORD record
ord-815115f9e63f44af8c24b705e17c934c
Source dataset
uspto-grants-2011_07
Patent number
US07981914B2

Reaction notes

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