反应详情

To a mixture of EXAMPLE 107B (0.5 g) and o-tolylboronic acid (175 mg) in tetrahydrofuran (5 ml) was added tris(dibenzylideneacetone)dipalladium(0) (25 mg), tri-t-butyl-phosphonium tetrafluoroborate (16 mg) and CsF (489 mg). The mixture was purged with Argon and stirred at room temperature for 24 hours. The mixture was diluted with ethyl acetate (200 mL) and washed with water and brine and dried over Na2SO4. After filtration, concentration of the solvent and column purification (5% ethyl acetate in hexane) provided EXAMPLE 107C.

1. customThe mixture was purged with Argon
2. additionThe mixture was diluted with ethyl acetate (200 mL)
3. washwashed with water and brine
4. dry with materialdried over Na2SO4
5. filtrationAfter filtration, concentration of the solvent and column purification (5% ethyl acetate in hexane)
6. customprovided EXAMPLE 107C