反应详情

To a solution of EXAMPLE 126A (205 mg) in dichloromethane (5 ml) and tetrahydrofuran (5 ml) at 0° C. was added dropwise N-bromosuccinimide (144 mg) in tetrahydrofuran (3 ml). The mixture was stirred while the ice bath slowly reached room temperature. The reaction mixture was concentrated and the residue was dissolved in dichloromethane and purified by flash chromatography, eluting with 0-100% dichloromethane in hexane to provide the desired product.

1. concentrationThe reaction mixture was concentrated
2. dissolutionthe residue was dissolved in dichloromethane
3. custompurified by flash chromatography
4. washeluting with 0-100% dichloromethane in hexane