Ethyl 5-(benzyloxy)-3-(2-isopropylphenyl)-1-(3-(naphthalen-1-yloxy)propyl)-1h-indole-2-carboxylate → Ethyl 5-hydroxy-3-(2-isopropylphenyl)-1-(3-(naphthalen-1-yloxy)propyl)-1h-indole-2-carboxylate

Participants

Reaction Steps

A mixture of EXAMPLE 149A (250 mg) and dihydroxypalladium (on carbon) (20 mg) in tetrahydrofuran was stirred a room temperature under a hydrogen atmosphere (30 psi) for 29 hours. The insoluble material was filtered off and the filtrate was concentrated. The residue was purified by flash chromatography, eluting with dichloromethane to provide the title compound.

Provenance & Evidence