HRID1013314

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOC(=O)c1c(-c2ccccc2C(C)C)c2cc(OCc3ccccc3)ccc2n1CCCOc1cccc2ccccc12

HCID67316990

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1c(-c2ccccc2C(C)C)c2cc(O)ccc2n1CCCOc1cccc2ccccc12

HCID67316919

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID178526213

未命名化合物

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

A mixture of EXAMPLE 149A (250 mg) and dihydroxypalladium (on carbon) (20 mg) in tetrahydrofuran was stirred a room temperature under a hydrogen atmosphere (30 psi) for 29 hours. The insoluble material was filtered off and the filtrate was concentrated. The residue was purified by flash chromatography, eluting with dichloromethane to provide the title compound.

WORKUP

后处理

filtrationThe insoluble material was filtered off
concentrationthe filtrate was concentrated
customThe residue was purified by flash chromatography
washeluting with dichloromethane

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-12e82d9001474511be1bacec816dedac
来源数据集: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07981888B2
来源说明: uspto-grants-2011_07

反应 SMILES

C([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH2:18][CH2:19][CH2:20][O:21][C:22]1[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH:25]=[CH:24][CH:23]=1)[C:13]([C:32]([O:34][CH2:35][CH3:36])=[O:33])=[C:12]2[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=1[CH:43]([CH3:45])[CH3:44])C1C=CC=CC=1>O1CCCC1.O[Pd]O>[OH:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH2:18][CH2:19][CH2:20][O:21][C:22]1[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH:25]=[CH:24][CH:23]=1)[C:13]([C:32]([O:34][CH2:35][CH3:36])=[O:33])=[C:12]2[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=1[CH:43]([CH3:44])[CH3:45]