Lithium hydroxide, monohydrate → HCID 57951462, compound

HRID 1013339Notes

Reaction equation

HRID 1013339 reaction equation
C([O:3][C:4]([CH:6]1[CH2:23][CH2:22][C:9]2([O:13][N:12]=[C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=3)[CH2:10]2)[CH2:8][CH2:7]1)=[O:5])C.O.[OH-].[Li+]>CO.O>[CH3:21][O:20][C:16]1[CH:15]=[C:14]([C:11]2[CH2:10][C:9]3([CH2:22][CH2:23][CH:6]([C:4]([OH:5])=[O:3])[CH2:7][CH2:8]3)[O:13][N:12]=2)[CH:19]=[CH:18][CH:17]=1

Participants

5

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 57951459HCID 57951459, compound

Product 1

HCID 57951462HCID 57951462, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A mixture of 3-(3-methoxyphenyl)-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylic acid ethyl ester (51 g, 161 mmol) in MeOH (1000 ml) and lithium hydroxide monohydrate (18 g, 241 mmol) in H2O (145 ml) was stirred overnight at RT.

Sources & evidence

ORD record
ord-b99fe12804e14a969a0ef4d38e222df8
Source dataset
uspto-grants-2011_07
Patent number
US07981883B2

Reaction notes

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