Hydrochloric Acid → HCID 67205028, compound

HRID 1013391Notes

Reaction equation

HRID 1013391 reaction equation
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:8][CH:7]1[C:19]1[CH:23]=[CH:22][S:21][CH:20]=1)=[O:5])C.Cl>>[CH2:12]([N:9]1[CH2:10][CH2:11][CH:6]([C:4]([OH:5])=[O:3])[CH:7]([C:19]2[CH:23]=[CH:22][S:21][CH:20]=2)[CH2:8]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 672067221-Benzyl-3-thiophen-3-yl-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 67205028HCID 67205028, compound

Procedure

The product from step c) (4.78 g, 14.5 mmol) was treated with 4 M HCl at 100° C. for 16 hours. Next, the reaction was evaporated to dryness, azeotroped with toluene (2×50 ml) and placed on the high vacuum to give the subtitle compound. MS calculated for C17H19NO2S−H 300, observed 300.

Workup

  1. customNext, the reaction was evaporated to dryness
  2. customazeotroped with toluene (2×50 ml)

Sources & evidence

ORD record
ord-b20fbd3283f64ebfa9cf5c51364dd322
Source dataset
uspto-grants-2011_07
Patent number
US07981919B2

Reaction notes

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