反应详情

温度

22 °C

The product of step f) (1.16 g, 4.3 mmol) in dichloroethane (21 ml) was treated with K2CO3 (2.38 g, 17.2 mmol) and Ace-Cl (1.86 ml, 17.2 mmol) at 80° C. for 16 hours. Next, the reaction mixture was filtered, concentrated and the residue was dissolved in anhydrous MeOH (25 ml) and stirred for 1 hour at 22° C. The MeOH was concentrated and triturated with ether to give 874 mg (94%) of the subtitle compound. MS calculated for C10H13NS+H 180, observed 180.

1. filtrationNext, the reaction mixture was filtered
2. concentrationconcentrated
3. dissolutionthe residue was dissolved in anhydrous MeOH (25 ml)
4. concentrationThe MeOH was concentrated
5. customtriturated with ether