HCID 67206463, compound → HCID 67206550, compound

HRID 1013409Notes

Reaction equation

HRID 1013409 reaction equation
C([O:3][C:4]([CH:6]1[CH:10]([C:11]2[CH:15]=[CH:14][S:13][CH:12]=2)[CH2:9][N:8]([CH:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH3:17])[CH2:7]1)=[O:5])C.C1NCC2C1CC1C(C#N)=CSC=12>Cl>[C:18]1([CH:16]([N:8]2[CH2:9][CH:10]([C:11]3[CH:15]=[CH:14][S:13][CH:12]=3)[CH:6]([C:4]([OH:5])=[O:3])[CH2:7]2)[CH3:17])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 67206463HCID 67206463, compoundHCID 683017591,2,3,3a,7,7a-Hexahydro-4-thia-2-aza-cyclopenta[alpha]pentalene-6-carbonitrile

Product 1

HCID 67206550HCID 67206550, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
80 °C

Procedure

The product from step b), diastereomer 1 (1.4 g, 4.3 mmol) was dissolved in 12 M HCl (10 mL) and was stirred at 80° C. for 12 hours. The reaction mix then was cooled to room temperature and evaporated to dryness to afford the subtitle compound. MS calculated for C17H19NO2S +H: 302, observed: 302.

Workup

  1. additionThe reaction mix
  2. temperaturethen was cooled to room temperature
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-14f1d9d3cc00421a9760ff6b14814118
Source dataset
uspto-grants-2011_07
Patent number
US07981919B2

Reaction notes

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