Chlorodiisopropylphosphine → Diisopropyl-p-tolyl-phosphane

HRID 1013453Notes

Reaction equation

HRID 1013453 reaction equation
[CH:1]([P:4]([CH:6]([CH3:8])[CH3:7])Cl)([CH3:3])[CH3:2].[C:9]1([CH3:17])[CH:14]=[CH:13][C:12]([Mg]Br)=[CH:11][CH:10]=1>C1COCC1>[CH:1]([P:4]([CH:6]([CH3:8])[CH3:7])[C:12]1[CH:13]=[CH:14][C:9]([CH3:17])=[CH:10][CH:11]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 538967ChlorodiisopropylphosphineHCID 178418370HCID 178418370, compound

Product 1

HCID 23470636Diisopropyl-p-tolyl-phosphane

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of diisopropylchlorophosphine (2 mL, 12.57 mmol) in THF (25 mL) at −78° C. was added 4-tolylmagnesium bromide (12.57 mL, 12.57 mmol) dropwise. After 1 h at −78° C., the reaction mixture was let warm to RT. The solvent was removed and material was used without further purification. MS: cal'd 209 (MH+), exp 209 (MH+).

Workup

  1. customThe solvent was removed
  2. custommaterial was used without further purification

Sources & evidence

ORD record
ord-a2774267b4a34807aced0efbc2cbd83d
Source dataset
uspto-grants-2011_07
Patent number
US07981874B2

Reaction notes

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