Hydrogen Peroxide → 1-(Diisopropyl-phosphinoyl)-4-methyl-benzene

HRID 1013454Notes

Reaction equation

HRID 1013454 reaction equation
[CH:1]([P:4]([CH:12]([CH3:14])[CH3:13])[C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][CH:6]=1)([CH3:3])[CH3:2].[OH:15]O>C(Cl)Cl>[CH:12]([P:4]([CH:1]([CH3:3])[CH3:2])([C:5]1[CH:6]=[CH:7][C:8]([CH3:11])=[CH:9][CH:10]=1)=[O:15])([CH3:14])[CH3:13]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 23470636Diisopropyl-p-tolyl-phosphane

Product 1

HCID 43736521-(Diisopropyl-phosphinoyl)-4-methyl-benzene

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a solution of diisopropyl-p-tolyl-phosphane (2.6 g, 12.48 mmol) in DCM (5 mL) at 0° C. was added hydrogen peroxide (4.08 mL, 13.31 mmol) dropwise. The reaction mixture was allowed to warm to RT. The reaction was diluted with DCM, washed with water, brine, dried (MgSO4), filtered and the solvent was evaporated under reduced pressure. The material was used without further purification. MS: cal'd 225 (MH+), exp 225 (MH+).

Workup

  1. washwashed with water, brine
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. customthe solvent was evaporated under reduced pressure
  5. customThe material was used without further purification

Sources & evidence

ORD record
ord-774850731e1b48f98c7ad34a2c7ad70b
Source dataset
uspto-grants-2011_07
Patent number
US07981874B2

Reaction notes

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