Lithium Hydroxide → HCID 57925949, compound

Participants

Reaction Steps

4-(5,5-Dimethyl-2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-ylmethyl)-benzoic acid methyl ester (0.23 g, 0.75 mmol) was made 0.25 M in dioxane and to this stirring solution was added 3 N aq LiOH (0.05 g, 2.26 mmol). The resulting mixture was stirred at ambient temperature for 4 hours. The reaction mixture was concentrated in vacuo and carried directly onto subsequent coupling without further purification: MS: cal'd 285 (MH+), exp 285 (MH+).

Provenance & Evidence