Lithium Hydroxide → HCID 57925949, compound

HRID 1013464Notes

Reaction equation

HRID 1013464 reaction equation
C[O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][P:11]2(=[O:19])[O:16][CH2:15][C:14]([CH3:18])([CH3:17])[CH2:13][O:12]2)=[CH:6][CH:5]=1.[Li+].[OH-]>O1CCOCC1>[CH3:17][C:14]1([CH3:18])[CH2:15][O:16][P:11]([CH2:10][C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:20])=[O:2])=[CH:5][CH:6]=2)(=[O:19])[O:12][CH2:13]1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 57925910HCID 57925910, compound

Product 1

HCID 57925949HCID 57925949, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4-(5,5-Dimethyl-2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-ylmethyl)-benzoic acid methyl ester (0.23 g, 0.75 mmol) was made 0.25 M in dioxane and to this stirring solution was added 3 N aq LiOH (0.05 g, 2.26 mmol). The resulting mixture was stirred at ambient temperature for 4 hours. The reaction mixture was concentrated in vacuo and carried directly onto subsequent coupling without further purification: MS: cal'd 285 (MH+), exp 285 (MH+).

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customcarried directly onto subsequent coupling without further purification

Sources & evidence

ORD record
ord-98cd10bf5b8d458cb6b44b4b0fca1ada
Source dataset
uspto-grants-2011_07
Patent number
US07981874B2

Reaction notes

Loading…