Hydrochloric Acid → HCID 86635273, compound

HRID 1013492Notes

Reaction equation

HRID 1013492 reaction equation
[CH3:1][P:2]1(=[O:16])[O:7][CH2:6][C:5]2([CH2:12][CH2:11][N:10](C([O-])=O)[CH2:9][CH2:8]2)[CH2:4][O:3]1.[ClH:17]>O1CCOCC1>[ClH:17].[CH3:1][P:2]1(=[O:16])[O:3][CH2:4][C:5]2([CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH2:6][O:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 866352753-Methyl-2,4-dioxa-9-aza-3-phosphaspiro[5.5]undecane-9-carboxylate 3-oxide

Product 1

HCID 86635273HCID 86635273, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3-methyl-2,4-dioxa-9-aza-3-phosphaspiro[5.5]undecane-9-carboxylate 3-oxide (975 mg, 3.19 mmol) was combined with 4.0 M HCl in dioxane (25 mL) and stirred at room temperature for 1 h. The resulting suspension was evaporated to a white solid that was slurried in EtOAc and filtered to give 3-methyl-2,4-dioxa-9-aza-3-phosphaspiro[5.5]undecane 3-oxide hydrochloride as a colorless solid. 1H NMR (DMSO-d6, 600 MHz) δ 8.99 (bs, 2H), 4.21-4.11 (m, 4H), 3.12-3.07 (m, 2H), 3.04-2.99 (m, 2H), 1.82-1.78 (m, 2H), 1.59-1.56 (m, 2H), 1.55 (d, J=17.0 Hz, 3H).

Workup

  1. customThe resulting suspension was evaporated to a white solid
  2. filtrationfiltered

Sources & evidence

ORD record
ord-b33bfd8c63374ade8b8c59827aa4fdf8
Source dataset
uspto-grants-2011_07
Patent number
US07981874B2

Reaction notes

Loading…