Hydrochloric Acid → HCID 86635277, compound

HRID 1013505Notes

Reaction equation

HRID 1013505 reaction equation
[CH:1]([P:4]([CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)([CH:6]([CH3:8])[CH3:7])=[O:5])([CH3:3])[CH3:2].[ClH:19].O1CCOCC1>>[ClH:19].[CH:1]([P:4]([CH2:9][CH2:10][NH2:11])([CH:6]([CH3:7])[CH3:8])=[O:5])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 57925889HCID 57925889, compound

Product 1

HCID 86635277HCID 86635277, compound

Procedure

tert-Butyl [2-(diisopropylphosphoryl)ethyl]carbamate (585 mg, 2.11 mmol) was combined with 4.0 M HCl in 1,4-dioxane (10.0 mL, 40.0 mmol) and stirred at room temperature for 30 minutes. The solution was evaporated to dryness to afford 2-(diisopropylphosphoryl)ethanamine hydrochloride as a colorless solid. 1H NMR (DMSO-d6, 600 MHz) 8.23 (bs, 3H), 2.99-2.90 (m, 2H), 2.08-1.93 (m, 4H), 1.05 (dd, J=14.7, 7.2 Hz, 6H), 1.03 (dd, J=15.2, 7.0 Hz, 6H). MS: cal'd 178 (MH+), exp 178 (MH+).

Workup

  1. customThe solution was evaporated to dryness

Sources & evidence

ORD record
ord-eb0bd7ed8a0b45839aabe8675f6cf417
Source dataset
uspto-grants-2011_07
Patent number
US07981874B2

Reaction notes

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