Acetyl chloride → HCID 57925824, compound

HRID 1013528Notes

Reaction equation

HRID 1013528 reaction equation
C(Cl)(=O)C.[Si]([O:12][CH2:13][C:14]1[CH:15]=[N:16][CH:17]=[C:18]([P:20]([CH3:23])([CH3:22])=[O:21])[CH:19]=1)(C(C)(C)C)(C)C>CO>[CH3:23][P:20]([C:18]1[CH:19]=[C:14]([CH2:13][OH:12])[CH:15]=[N:16][CH:17]=1)([CH3:22])=[O:21]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 67316972HCID 67316972, compound

Product 1

HCID 57925824HCID 57925824, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

Acetyl chloride (0.044 ml, 0.625 mmol) was added to 3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-(dimethylphosphoryl)pyridine (170 mg, 0.568 mmol) stirred in MeOH (1 ml) at 0° C. and the mixture was stirred at 0° C. for 1 h. The reaction was concentrated and left on high vac pump to dry. [5-(dimethylphosphoryl)pyridin-3-yl]methanol was taken on to next reaction crude. MS: cal'd 186 (MH+), exp 186 (MH+).

Workup

  1. concentrationThe reaction was concentrated
  2. waitleft on high vac pump
  3. customto dry
  4. custom[5-(dimethylphosphoryl)pyridin-3-yl]methanol was taken on to next reaction crude

Sources & evidence

ORD record
ord-840592587b564d5aa1dae2dd915fd25c
Source dataset
uspto-grants-2011_07
Patent number
US07981874B2

Reaction notes

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