Acetyl chloride → HCID 57925824, compound

Participants

Reaction Conditions

Reaction Steps

Acetyl chloride (0.044 ml, 0.625 mmol) was added to 3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-(dimethylphosphoryl)pyridine (170 mg, 0.568 mmol) stirred in MeOH (1 ml) at 0° C. and the mixture was stirred at 0° C. for 1 h. The reaction was concentrated and left on high vac pump to dry. [5-(dimethylphosphoryl)pyridin-3-yl]methanol was taken on to next reaction crude. MS: cal'd 186 (MH+), exp 186 (MH+).

Provenance & Evidence