Trifluoroacetic acid → HCID 57925841, compound

HRID 1013548Notes

Reaction equation

HRID 1013548 reaction equation
[CH3:1][O:2][P:3]([C:7]1[CH:8]=[C:9](/[CH:13]=[CH:14]/[C:15]([O:17]C(C)(C)C)=[O:16])[CH:10]=[CH:11][CH:12]=1)([O:5][CH3:6])=[O:4].C(O)(C(F)(F)F)=O>ClCCl>[CH3:1][O:2][P:3]([C:7]1[CH:8]=[C:9](/[CH:13]=[CH:14]/[C:15]([OH:17])=[O:16])[CH:10]=[CH:11][CH:12]=1)([O:5][CH3:6])=[O:4]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57925827HCID 57925827, compound

Product 1

HCID 57925841HCID 57925841, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

tert-butyl (2E)-3-[3-(dimethoxyphosphoryl)phenyl]acrylate was dissolved in dichloromethane (6 ml). TFA (3 ml, 38.9 mmol) was added. The reaction was allowed to stir for approximately one and a half hours. The reaction was complete as indicated by LCMS. The reaction was diluted with DCM and washed with brine. The aqueous layer was extracted three times with DCM. The combined organic layer was dried over Na2SO42, filtered, and concentrated. MS: calc'd 257 (MH+), exp 257 (MH+)

Workup

  1. washwashed with brine
  2. extractionThe aqueous layer was extracted three times with DCM
  3. customThe combined organic layer was dried over Na2SO42
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-52f2f7514d9246e7ba7f12b5059d9deb
Source dataset
uspto-grants-2011_07
Patent number
US07981874B2

Reaction notes

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