Phosphorus oxychloride → 3-Bromo-8-chloro-1,5-naphthyridine

HRID 1013625Notes

Reaction equation

HRID 1013625 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](O)=[CH:7][CH:8]=[N:9]2)=[N:4][CH:3]=1.P(Cl)(Cl)([Cl:15])=O>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[N:9][CH:8]=[CH:7][C:6]=2[Cl:15]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178516370HCID 178516370, compound

Product 1

HCID 134591373-Bromo-8-chloro-1,5-naphthyridine

Procedure

7-Bromo-1,5-naphthyridin-4-ol (7.0 g) and phosphoryl chloride (200 mL) were refluxed for 5 h in a RBF fitted with a reflux condenser. Excess POCl3 was distilled off under reduced pressure and the residue poured onto ice. This cold mixture was carefully neutralized with aq. ammonia, which caused an exotherm. The resulting solid was filtered, washed with water and dried. The product was recrystallized from n-heptane to give white needles of 3-bromo-8-chloro-1,5-naphthyridine.

Workup

  1. customfitted with a reflux condenser
  2. distillationExcess POCl3 was distilled off under reduced pressure
  3. additionthe residue poured onto ice
  4. filtrationThe resulting solid was filtered
  5. washwashed with water
  6. customdried
  7. customThe product was recrystallized from n-heptane

Sources & evidence

ORD record
ord-45a8856550224fa9a9839fdf8f11ce0a
Source dataset
uspto-grants-2011_07
Patent number
US07981891B2

Reaction notes

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