反应详情

Combine 1H-indazol-6-ylamine (12.45 g, 93.6 mmol) and 5% Rh/C (6.13 g) in ethanol (300 mL) and heat at 120° C. for 72 hours under ˜1000 psi H2. Cool the reaction and filter through hyflo. Remove the solvent in vacuo and purify the crude product with 10% 2 M NH3 in MeOH in CH2Cl2 and re-purify mixed fractions with 15% 2 M NH3 in MeOH in CH2Cl2 to afford 4.80 g (37%) of the titled product. MS (m/z): 138 (M+1).

1. temperatureCool
2. customthe reaction
3. filtrationfilter through hyflo
4. customRemove the solvent in vacuo
5. custompurify the crude product with 10% 2 M NH3 in MeOH in CH2Cl2
6. customre-purify
7. additionmixed fractions with 15% 2 M NH3 in MeOH in CH2Cl2