Hydrazine hydrate (1:1) → HCID 178480054, compound

HRID 1013836Notes

Reaction equation

HRID 1013836 reaction equation
[Cl:1][C:2]1[CH:25]=[C:24]([C:26]2[CH:27]=[N:28][N:29]([CH3:31])[CH:30]=2)[CH:23]=[CH:22][C:3]=1[CH2:4][CH:5]1[CH2:9][CH2:8][N:7]([CH:10]2[CH2:15][CH2:14][C:13](=O)[C:12](=[CH:17][N:18](C)C)[CH2:11]2)[C:6]1=[O:21].O.[NH2:33]N>CO>[Cl:1][C:2]1[CH:25]=[C:24]([C:26]2[CH:27]=[N:28][N:29]([CH3:31])[CH:30]=2)[CH:23]=[CH:22][C:3]=1[CH2:4][CH:5]1[CH2:9][CH2:8][N:7]([CH:10]2[CH2:15][CH2:14][C:13]3[C:12](=[CH:17][NH:18][N:33]=3)[CH2:11]2)[C:6]1=[O:21]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 67317952HCID 67317952, compound

Product 1

HCID 178480054HCID 178480054, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Dissolve 3-[2-Chloro-4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-1-(3-dimethylaminomethylene-4-oxo-cyclohexyl)-pyrrolidin-2-one (Preparation 30) (0.327 g, 0.745 mmol) in methanol (3.0 mL), and hydrazine hydrate (0.038 mL) stir the resulting orange solution for 17 hours at room temperature. Filter the mixture, rinse with cold methanol and vacuum dry to 0.138 g of a solid. MS (m/z): 410 (M+1).

Workup

  1. filtrationFilter the mixture
  2. washrinse with cold methanol and vacuum
  3. dry with materialdry to 0.138 g of a solid

Sources & evidence

ORD record
ord-9bbb66d50fcc4326a936b7fe4ff0207c
Source dataset
uspto-grants-2011_07
Patent number
US07981918B2

Reaction notes

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