Sodium Carbonate → HCID 178449324, compound

HRID 1013844Notes

Reaction equation

HRID 1013844 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4](C2C=CC(C(N3CCN(C)CC3)=O)=CC=2)[CH:5]=[CH:6][C:7]=1[CH2:8][CH:9]1[CH2:13][CH2:12][N:11]([CH:14]2[CH2:22][CH2:21][C:20]3[C:16](=[CH:17][NH:18][N:19]=3)[CH2:15]2)[C:10]1=[O:23].BrC1C=CC(CC2CCN(C3CCC4C(=CNN=4)C3)C2=O)=C([Cl:62])C=1.CN1CC[N:67]([C:70]([C:72]2[CH:77]=CC(B3OC(C)(C)C(C)(C)O3)=C[CH:73]=2)=O)CC1.[C:87]([O-:90])([O-])=O.[Na+].[Na+]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[Cl:62][C:6]1[CH:5]=[C:4]([CH:3]=[C:2]([Cl:1])[C:7]=1[CH2:8][CH:9]1[CH2:13][CH2:12][N:11]([CH:14]2[CH2:22][CH2:21][C:20]3[C:16](=[CH:17][NH:18][N:19]=3)[CH2:15]2)[C:10]1=[O:23])[C:87]([NH:67][CH2:70][CH:72]([CH3:77])[CH3:73])=[O:90]

Participants

6

Reactant 4

HCID 10340Sodium CarbonateHCID 27600304-(4-Methylpiperazine-1-carbonyl)phenylboronic acid pinacol esterHCID 178481035HCID 178481035, compoundHCID 178515501HCID 178515501, compound

Product 1

HCID 178449324HCID 178449324, compound

Reagents, catalysts & solvents 1

HCID 178418397HCID 178418397, compoundCatalyst

Procedure

In Scheme W, 3-[3-Chloro-4′-(4-methyl-piperazine-1-carbonyl)-biphenyl-4-ylmethyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one is prepared by treatment of 3-(4-Bromo-2-chloro-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one with (4-Methyl-piperazin-1-yl)-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone in the presence of Pd(PPh3)4 and Na2CO3.

Sources & evidence

ORD record
ord-9c26db1ad0d64ecda3889d5d5c161a8d
Source dataset
uspto-grants-2011_07
Patent number
US07981918B2

Reaction notes

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