Hydrochloric Acid → HCID 66878437, compound

HRID 1014012Notes

Reaction equation

HRID 1014012 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([S:13](=[O:16])(=[O:15])[NH2:14])=[C:6]([CH:12]=1)[CH2:7][NH:8]C(=O)C.[ClH:17]>C(O)C>[ClH:17].[NH2:8][CH2:7][C:6]1[CH:12]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=1[S:13]([NH2:14])(=[O:16])=[O:15]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66877905HCID 66877905, compound

Product 1

HCID 66878437HCID 66878437, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(Step 3) To a solution of N-(5-fluoro-2-sulfamoylbenzyl)acetamide obtained in Step 2 (2.7 g) in ethanol (20 ml) was added hydrochloric acid (10 ml) at room temperature, and the mixture was stirred with heating under reflux for 3 hr, and then overnight at 80° C. The solvent was evaporated under reduced pressure. The residue was collected by filtration, and washed with diethyl ether to give 2-(aminomethyl)-4-fluorobenzenesulfonamide hydrochloride (1.49 g) as a white solid.

Workup

  1. temperaturewith heating
  2. temperatureunder reflux for 3 hr
  3. customovernight
  4. customat 80° C
  5. customThe solvent was evaporated under reduced pressure
  6. filtrationThe residue was collected by filtration
  7. washwashed with diethyl ether

Sources & evidence

ORD record
ord-8c393f647ff244a591106bc030c6ff34
Source dataset
uspto-grants-2011_07
Patent number
US07982044B2

Reaction notes

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