N-Hydroxyacetamidine → HCID 11286666, compound

HRID 1014065Notes

Reaction equation

HRID 1014065 reaction equation
[C:1](=[N:4][OH:5])([NH2:3])[CH3:2].[CH:6]1([C:9](=[O:15])[CH2:10][C:11](OC)=O)[CH2:8][CH2:7]1>C1(C)C=CC=CC=1>[CH:6]1([C:9](=[O:15])[CH2:10][C:11]2[O:5][N:4]=[C:1]([CH3:2])[N:3]=2)[CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 30926N-HydroxyacetamidineHCID 101300163-Cyclopropyl-3-Oxopropionic Acid Methyl Ester

Product 1

HCID 11286666HCID 11286666, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
130 °C

Procedure

Under an inert atmosphere, acetamidoxime (1.56 g) is added to a solution of methyl 3-cyclopropyl-3-oxopropanoate (3.0 g) in 50 ml of toluene; the stirred mixture is heated to 130° C. while distilling off the solvent and methanol formed in the reaction.

Workup

  1. distillationwhile distilling off the solvent and methanol
  2. customformed in the reaction

Sources & evidence

ORD record
ord-b1f25107b023422998b604f5eeb55687
Source dataset
uspto-grants-2011_07
Patent number
US07982047B2

Reaction notes

Loading…