Bromine → HCID 11314987, compound

HRID 1014066Notes

Reaction equation

HRID 1014066 reaction equation
[Br:1]Br.[Cl:3][C:4]1[CH:9]=[C:8]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:7]=[CH:6][C:5]=1[C:14](=[O:21])[CH2:15][C:16]([CH:18]1[CH2:20][CH2:19]1)=[O:17]>ClCCl>[Br:1][CH:15]([C:16]([CH:18]1[CH2:19][CH2:20]1)=[O:17])[C:14]([C:5]1[CH:6]=[CH:7][C:8]([S:10]([CH3:13])(=[O:12])=[O:11])=[CH:9][C:4]=1[Cl:3])=[O:21]

Participants

4

Reactant 2

HCID 24408BromineHCID 110120521,3-Propanedione, 1-[2-chloro-4-(methylsulfonyl)phenyl]-3-cyclopropyl-

Product 1

HCID 11314987HCID 11314987, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
5 °C

Procedure

Under an inert atmosphere, bromine (0.24 g) is slowly added dropwise to a solution of (1-[2-chloro-4-(methylsulphonyl)phenyl]-3-(cyclopropyl)propan-1,3-dione (0.43 g) in 25 ml of dichloromethane cooled to 5° C., then the mixture is stirred overnight at room temperature.

Sources & evidence

ORD record
ord-5dda7d2c536f411bb25fa53385e98490
Source dataset
uspto-grants-2011_07
Patent number
US07982047B2

Reaction notes

Loading…