Hydrochloric Acid → (R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]-acetanilide dihydrochloride

HRID 1014069Notes

Reaction equation

HRID 1014069 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][NH:19][CH2:20][C@H:21]([OH:28])[C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:13][CH:12]=2)=[O:9])[N:6]=1.[ClH:29]>O1CCOCC1>[ClH:29].[ClH:29].[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([NH:10][C:11]2[CH:12]=[CH:13][C:14]([CH2:17][CH2:18][NH:19][CH2:20][C@H:21]([OH:28])[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)=[CH:15][CH:16]=2)=[O:9])[N:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9865528Mirabegron

Product 1

HCID 86595764(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]-acetanilide dihydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

20.0 g of (R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide was dissolved in 1,4-dioxane, to which was then added 8.41 mL of concentrated hydrochloric acid. A generated crystal was collected by filtration to obtain 25.0 g of (R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]-acetanilide dihydrochloride.

Workup

  1. filtrationA generated crystal was collected by filtration

Sources & evidence

ORD record
ord-d88b738a79b14b58a3240f774068248b
Source dataset
uspto-grants-2011_07
Patent number
US07982049B2

Reaction notes

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